A hypergraph transformer method for brain disease diagnosis

Front Med (Lausanne). 2024 Nov 14:11:1496573. doi: 10.3389/fmed.2024.1496573. eCollection 2024.

Abstract

Objective: To address the high-order correlation modeling and fusion challenges between functional and structural brain networks.

Method: This paper proposes a hypergraph transformer method for modeling high-order correlations between functional and structural brain networks. By utilizing hypergraphs, we can effectively capture the high-order correlations within brain networks. The Transformer model provides robust feature extraction and integration capabilities that are capable of handling complex multimodal brain imaging.

Results: The proposed method is evaluated on the ABIDE and ADNI datasets. It outperforms all the comparison methods, including traditional and graph-based methods, in diagnosing different types of brain diseases. The experimental results demonstrate its potential and application prospects in clinical practice.

Conclusion: The proposed method provides new tools and insights for brain disease diagnosis, improving accuracy and aiding in understanding complex brain network relationships, thus laying a foundation for future brain science research.

Keywords: brain disease diagnosis; brain network; high-order correlation; hypergraph computation; transformer.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties (No.SZGSP013), the Science and Technology Planning Project of Shenzhen Municipality (20210617155253001), and the National Natural Science Foundation of China (62401330).