Ethnopharmacological Perspective for Treatment of Epilepsy: An Updated Review

Sunishtha Kalra; Saurabh Bhatia; Ahmed Al Harrasi; Syam Mohan; Himanshu Sachdeva; Divya Sharma; Vikas Budhwar; Manjusha Choudhary; Rohit Malik

doi:10.1155/2024/8052659

Ethnopharmacological Perspective for Treatment of Epilepsy: An Updated Review

Scientifica (Cairo). 2024 Nov 20:2024:8052659. doi: 10.1155/2024/8052659. eCollection 2024.

Authors

Sunishtha Kalra^{1

2}, Saurabh Bhatia^{3

4}, Ahmed Al Harrasi³, Syam Mohan^{4

5

6}, Himanshu Sachdeva², Divya Sharma⁷, Vikas Budhwar², Manjusha Choudhary¹, Rohit Malik^{8

9}

Affiliations

¹ Department of Pharmacology, Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana 136119, India.
² Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana 124001, India.
³ Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Oman.
⁴ School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand 248007, India.
⁵ Substance Abuse and Toxicology Research Centre, Jazan University, Jazan 82912, Saudi Arabia.
⁶ Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai 602105, India.
⁷ Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India.
⁸ Department of Pharmacology, ICFAI School of Pharmaceutical Sciences, The ICFAI University, Jaipur, Rajasthan, India.
⁹ Department of Pharmacology, SRM Modi Nagar College of Pharmacy, SRMIST, Delhi-NCR Campus, Ghaziabad, India.

Abstract

Plants have been used as healing agents since humanity began. This review presents the plant profiles inhabiting the world regarding their traditional usage by various tribes/ethnic groups for the treatment of epilepsy. The bibliographic investigation was carried out by analyzing standard reference textbooks, Science Direct, Google Scholar, Scopus, Medline, Web of Science, and PubMed databases. Search terms and keywords used for the search were epilepsy, medicinal plants for epilepsy, herbal remedies used in the treatment of epilepsy, and traditional antiepilepsy medication. This review article was prepared by including the biological names of plants/their parts/extracts/compounds/doses/models/results. Further, experimentally explored 15 potential medicinal plants have also been explored in detail. The present review was prepared by including 114 plants from 3 books, 83 research, and 59 review articles. This review indicates that the list of medicinal plants presented in this review might be useful to researchers for preliminary screening of potential antiepileptic agents.

Keywords: Ethnopharmacology; GABA; antiepileptic drugs; epilepsy; glutamate; traditional plants.

Publication types

Review