Background: Reduction in adult height by high-dose sex steroids was introduced decades ago. Here, we present the impact of lower doses of sex steroids on the predicted adult height in tall stature.
Methods: This single-center retrospective observational study included 22 tall children treated with low-dose sex steroids. Patients with familial tall stature, constitutional advance of growth or Marfan syndrome were included. Anthropometric measurements at the commencement of treatment, six-monthly intervals on treatment, cessation of treatment, and at final assessment, were evaluated. Bone age (BA) determination, and adult height predictions (PAH) were made using both the tables of Bayley-Pinneau (BP) and Tanner Whitehouse (TW) mark II methods.
Results: The standard deviation scores (SDS) of height over time were not statistically significant. The final height was significantly lower than the predicted height in girls whereas it was not significantly lower than predicted height in boys. In Marfan cases, the final height was only lower than the prediction of TW rather than BP. Non Marfan cases had significantly lower final height than both the predicted heights. Starting treatment in early BA (<10 years) did not affect the last height SDS or the difference between predicted height and final height.
Conclusion: Sex difference, sex steroid dosage, differences in treatment duration and differences in BA measurement method, PAH method, BA and chronological age at the start of treatment may all influence the therapy response. Shortcomings about these influences can be overcome in future prospective studies with a larger sample size.
S. Karger AG, Basel.