Growth factors were introduced to increase predictability in periodontal regeneration and have since been widely applied in dentistry. This narrative review article highlights histological and latest findings of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human fibroblast growth factor-2 (rhFGF-2) for periodontal regeneration. rhPDGF-BB enhances the proliferation and chemotaxis of periodontal ligament and alveolar bone cells. The optimal dose for rhPDGF-BB, in combination with beta-tricalcium phosphate, is 0.3 mg/ml. It is approved in the United States, Canada, and Taiwan for use in periodontal regeneration and treatment of gingival recession. rhFGF-2 promotes periodontal wound healing through mitogenic and angiogenic effects on mesenchymal cells in the periodontal ligament. It is approved in Japan at an optimal dose of 0.3% for periodontal regeneration in intrabony defects. Both recombinant growth factors show histological evidence of new bone, cementum, and periodontal ligament. Clinical studies demonstrate improved clinical attachment levels and defect resolution for treating intrabony and furcation periodontal defects. Presented clinical cases and consensus reports may serve as a reference for clinicians. rhPDGF-BB and rhFGF-2 are safe and effective biologics that can be applied to improve the outcomes of periodontal regeneration.
Keywords: growth factor; periodontal disease; periodontal regeneration; rhFGF-2; rhPDGF-BB.
Use of growth factors to rebuild lost tissues from gum disease Growth factors are unique proteins introduced to make gum and bone regeneration more predictable in dental treatments. They are now widely used in dentistry. This review focuses on two specific growth factors: recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human fibroblast growth factor-2 (rhFGF-2). Key Points: - rhPDGF-BB helps gum and bone cells grow and move to the damaged area. The best dose is 0.3 mg/mL, usually combined with a material called beta-tricalcium phosphate (β-TCP). It’s approved in the US, Canada, and Taiwan for regenerating tissue and treating gum recession. - rhFGF-2 aids in healing gum wounds by encouraging cell growth and new blood vessel formation. It’s approved in Japan at a dose of 0.3% for treating deep gum and bone defects. Both growth factors have been shown to help form new bone, cementum (the surface layer of the tooth root), and periodontal ligament (the tissue that helps hold the teeth in place). Clinical studies have found that they improve the connection between the tooth and gum and help resolve deep defects. Case studies and expert reports provide valuable guidance for dentists. Both rhPDGF-BB and rhFGF-2 are safe and effective for enhancing gum and bone regeneration in dental treatments.
© The Author(s), 2024.