Ferroptosis and its implications in bone-related diseases

PeerJ. 2024 Nov 26:12:e18626. doi: 10.7717/peerj.18626. eCollection 2024.

Abstract

Ferroptosis, a recently recognized form of regulated cell death (RCD) characterized by iron-dependent lipid peroxide accumulation, has emerged as a noteworthy regulator in various bone-related diseases, including osteoporosis (OP), osteoarthritis (OA), and osteosarcoma (OS). OS primarily afflicts the elderly, rendering them susceptible to fractures due to increased bone fragility. OA represents the most prevalent arthritis in the world, often observed in the aging population. OS predominantly manifests during adolescence, exhibiting an aggressive nature and bearing a significantly unfavorable prognosis. In this review article, we present an overview of the characteristics and mechanism of ferroptosis and its involvement in bone-related diseases, with a particular focus on OP, OA, and OS. Furthermore, we summarize chemical compounds or biological factors that impact bone-related diseases by regulating ferroptosis. Through an in-depth exploration of ferroptosis based on current research findings, this review provides promising insights for potential therapeutic approaches to effectively manage and mitigate the impact of these bone-related pathological conditions.

Keywords: Ferroptosis; Osteoarthritis; Osteoporosis; Osteosarcoma.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Diseases / metabolism
  • Bone Diseases / pathology
  • Bone Diseases / therapy
  • Bone Neoplasms / metabolism
  • Bone Neoplasms / pathology
  • Bone Neoplasms / therapy
  • Ferroptosis* / physiology
  • Humans
  • Osteoarthritis* / metabolism
  • Osteoarthritis* / pathology
  • Osteoarthritis* / physiopathology
  • Osteoporosis* / metabolism
  • Osteoporosis* / pathology
  • Osteoporosis* / physiopathology
  • Osteoporosis* / therapy
  • Osteosarcoma* / metabolism
  • Osteosarcoma* / pathology

Grants and funding

This study was supported by the Shandong Provincial Natural Science Foundation of China (Grant Nos. ZR2024MH112, ZR2016HM60 and ZR2024QH628), the Weifang Municipal Health Commission Scientific Research Project (Grant No. WFWSJK-2022-231), the Support Program for Youth Innovation Technology in Colleges and Universities of Shandong Province of China (Grant No. 2019KJK004), the Shandong Medical and Health Science and Technology Development Plan Project (Grant No. 2019WS606) and the Science and Technology Innovation Foundation for the University Students of Shandong Second Medical University (Grant No.2023065). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.