Active particles are self-propelling in nature due to the generation of a fore-aft asymmetry in the concentration of solutes around their surface. Both the surface activity and mobility play an important role in the particle dynamics. The solutes are the products of the chemical reaction between the active particle surface and suspending medium. Unlike Janus particles, isotropic active particles have been shown to undergo spontaneous self-propulsion beyond a critical particle size (or the Péclet number). Compared to Janus active particles, there is a third ingredient, namely, advection-induced instability that dictates the dynamics of such particles. The present study numerically investigates the role played by shear rate-dependent viscosity of a suspending medium in the self-phoretic dynamics of such isotropic active particles. Towards this, a non-Newtonian Carreau fluid is taken as the suspending medium. One of the important findings of this study is the presence of a second critical Péclet number beyond which the spontaneous motion of the particle ceases to exist. Even though this critical Péclet number had been previously investigated for Newtonian fluids, strong dependence of the former on the rheology of the suspending medium was not explored. The analysis also shows that a shear thinning fluid significantly reduces the maximum velocity of the particle. In addition, confinement is found to have a significant effect on the axial propulsive velocity of the particle suspended in a Carreau fluid.