Acetogens are a diverse group of anaerobic bacteria that are capable of carbon dioxide fixation and have for long fascinated scientists due to their unique metabolic prowess. Historically, acetogens have been recognized for their remarkable ability to grow and to produce acetate from different one-carbon sources, including carbon dioxide, carbon monoxide, formate, methanol, and methylated organic compounds. The key metabolic pathway in acetogens responsible for converting these one-carbon sources is ́the Wood-Ljungdahl pathway. This review offers a comprehensive overview of the latest discoveries that are related to acetogens. It delves into a variety of topics, including newly isolated acetogens, their taxonomy and physiology and highlights novel metabolic properties. Additionally, it explores metabolic engineering strategies that are designed to expand the product range of acetogens or to understand specific traits of their metabolism. Lastly, the review presents innovative gas fermentation techniques within the context of industrial applications.
Keywords: Acetogens; Gas fermentation; Metabolic engineering; Metabolic potential; Wood-Ljungdahl pathway.
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