Framework Nucleic Acids: Innovative Tools for Cellular Sensing and Therapeutics

Yihan Zhang; Yuting Li; Bowen Fang; Yi Du; Pai Peng

doi:10.1002/cbic.202400810

Framework Nucleic Acids: Innovative Tools for Cellular Sensing and Therapeutics

Chembiochem. 2024 Dec 9:e202400810. doi: 10.1002/cbic.202400810. Online ahead of print.

Authors

Yihan Zhang¹, Yuting Li², Bowen Fang², Yi Du¹, Pai Peng³

Affiliations

¹ Anhui Medical University, School of Life Sciences, CHINA.
² Anhui Medical University, School of Life Sciences, 230032, Hefei, CHINA.
³ Anhui Medical University, School of Life Sciences, Hefei, CHINA.

PMID: 39653648
DOI: 10.1002/cbic.202400810

Abstract

As emerging biomaterials, framework nucleic acids (FNAs) have recently demonstrated great potential in the biomedical field due to their high programmability, biocompatibility, unique structural diversity, and precise molecular design capabilities. This review focuses on the applications of FNAs in cellular sensing and disease treatment. First, we systematically introduce the applications of FNAs in cellular sensing, including their precise recognition and response to the extracellular tumor microenvironment, cell membrane proteins, and intracellular biomarkers. Subsequently, we review the potential of FNAs in disease treatment, covering their applications and development in drug delivery, regulation of cell behavior, and immunomodulation. We also discuss the limitations and potential role of FNAs in personalized medicine, precision diagnostics, and advanced therapies. The broad application of FNAs is expected to drive significant breakthroughs in future biomedical technological innovations and clinical translation.

Keywords: Advanced Therapies; Cell Behavior Regulation; DNA Biosensors; DNA nanotechnology; Framework Nucleic Acids.