Abstract
The possible relationship of chromosome abnormalities and gene amplification with tumor growth and sensitivity to chemotherapy was studied in six human neuroblastomas transplanted in nude mice. Our results suggest that cells with DMs are more sensitive to Aclacinomycin A than those with HSRs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use*
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Cell Division / drug effects
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Chromosome Aberrations*
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DNA, Neoplasm / genetics*
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Drug Resistance
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Gene Amplification*
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Humans
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Mice
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Mice, Nude
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Neoplasm Transplantation
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Neuroblastoma / drug therapy
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Neuroblastoma / genetics*
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Neuroblastoma / pathology
Substances
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Antineoplastic Agents
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DNA, Neoplasm