Ticlopidine as a hemorrhagic risk factor in coronary surgery

Drug Intell Clin Pharm. 1985 Sep;19(9):673-6. doi: 10.1177/106002808501900912.

Abstract

We retrospectively reviewed the postoperative hemorrhagic risk in patients undergoing surgery for coronary revascularization who had received platelet antiaggregants preoperatively. A significant increase in postoperative hemorrhage and a higher percentage of reoperations for this reason was observed in the patients treated with ticlopidine. However, there were no major differences in the platelet counts among the groups compared.

MeSH terms

  • Adult
  • Coronary Disease / surgery*
  • Female
  • Hemorrhage / chemically induced*
  • Humans
  • Male
  • Platelet Aggregation / drug effects
  • Platelet Count
  • Postoperative Complications
  • Retrospective Studies
  • Risk
  • Thiophenes / adverse effects*
  • Ticlopidine

Substances

  • Thiophenes
  • Ticlopidine