Thymus carcinoid

Pathol Res Pract. 1985 Oct;180(4):445-51. doi: 10.1016/s0344-0338(85)80119-9.

Abstract

A carcinoid of the thymus was studied by light- and electron-microscopy, immunohistology and flow-cytometry. The tumor showed a ribbon- and festoon-like growth-pattern with foci of necrosis, invasion of vessels and infiltration of mediastinal lymph nodes. The cytoplasma of the tumor-cells contained neuroendocrine granula and immunohistochemistry of ACTH was positive. The tumor-cells were connected by desmosomes, correlating to a pre-keratin positive immunohistology. In flow-cytometry the tumor-cells showed a near haploid DNA aneuploidy which is an extremely rare finding in solid tumors and in the few cases described indicative for treatment resistance.

Publication types

  • Case Reports

MeSH terms

  • Carcinoid Tumor / diagnosis
  • Carcinoid Tumor / pathology*
  • Carcinoid Tumor / surgery
  • Carcinoid Tumor / ultrastructure
  • Female
  • Flow Cytometry
  • Humans
  • Lymphatic Metastasis
  • Microscopy, Electron
  • Middle Aged
  • Necrosis
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / pathology*
  • Thyroid Neoplasms / surgery
  • Thyroid Neoplasms / ultrastructure