Transport of methotrexate into normal haemopoietic cells and into leukaemic cells and its effects on DNA synthesis

MeSH terms

• Bone Marrow / metabolism*
• Bone Marrow Cells*
• Carbon Radioisotopes
• Culture Techniques
• Cyclic AMP
• DNA / biosynthesis*
• Dactinomycin / pharmacology
• Deoxyuridine / metabolism
• Folic Acid / metabolism
• Humans
• Lectins
• Leukemia, Lymphoid / metabolism*
• Leukemia, Myeloid / metabolism
• Lymphocyte Activation
• Methotrexate / antagonists & inhibitors
• Methotrexate / metabolism*
• Mitosis / drug effects
• Phosphodiesterase Inhibitors
• Puromycin / pharmacology
• RNA / biosynthesis
• Theophylline / pharmacology
• Thymidine / metabolism
• Tritium