Relationships between tricyclic antidepressant concentrations, 1-3H-noradrenaline uptake and chronotropic effect in isolated rat atria

Eur J Pharmacol. 1974 Oct;28(2):368-75. doi: 10.1016/0014-2999(74)90291-x.
No abstract available

MeSH terms

  • Amitriptyline / pharmacology
  • Animals
  • Antidepressive Agents / pharmacology*
  • Carbon Radioisotopes
  • Chromatography, Thin Layer
  • Clomipramine / pharmacology
  • Dealkylation
  • Desipramine / analogs & derivatives
  • Desipramine / pharmacology
  • Dose-Response Relationship, Drug
  • Doxepin / analogs & derivatives
  • Doxepin / pharmacology
  • Drug Synergism
  • Female
  • Heart Atria / drug effects*
  • Heart Rate / drug effects*
  • Norepinephrine / metabolism*
  • Nortriptyline / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Stimulation, Chemical
  • Time Factors
  • Tritium

Substances

  • Antidepressive Agents
  • Carbon Radioisotopes
  • Tritium
  • Doxepin
  • Amitriptyline
  • Nortriptyline
  • Clomipramine
  • Desipramine
  • Norepinephrine