Abstract
The pharmacology, antimicrobial activity and clinical uses of cephalexin, a semi-synthetic derivative of cephalosporin C, are described.
Cephalexin is active, when taken by mouth, against Gram-positive cocci, including penicillinase-producing staphylococci, and against many Gram-negative organisms including Gram-negative rods.
There is a low incidence of side effects.
MeSH terms
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Animals
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Cephalosporins / adverse effects
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Cephalosporins / pharmacology
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Cephalosporins / therapeutic use*
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Gonorrhea / drug therapy
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Humans
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Penicillinase / biosynthesis
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Respiratory Tract Infections / drug therapy
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Sepsis / drug therapy
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Staphylococcal Infections / drug therapy
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Staphylococcus / drug effects
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Staphylococcus / metabolism
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Urinary Tract Infections / drug therapy
Substances
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Cephalosporins
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Penicillinase