Abstract
Three opioid peptide precursors have been isolated and characterized in endocrine and nervous tissue: pro-opiomelanocortin, pro-enkephalin, and pro-dynorphin. Since each of those opioid peptide systems have been extensively characterized both biochemically and anatomically, this review will focus on strategies for studying the regulation of these systems at the levels of gene transcription, message translation, post-translational processing, secretion, and target cell receptor interaction.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Brain / metabolism
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DNA
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Endorphins / biosynthesis*
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Endorphins / metabolism
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Enkephalins / metabolism
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Neurons / metabolism
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Pituitary Gland, Anterior / metabolism
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Pro-Opiomelanocortin / metabolism
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Protein Biosynthesis*
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Protein Precursors / metabolism
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Protein Processing, Post-Translational*
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RNA, Heterogeneous Nuclear / metabolism
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RNA, Messenger / metabolism
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Receptors, Opioid / physiology
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Stress, Physiological / metabolism
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Tissue Distribution
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Transcription, Genetic*
Substances
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Endorphins
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Enkephalins
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Protein Precursors
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RNA, Heterogeneous Nuclear
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RNA, Messenger
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Receptors, Opioid
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proenkephalin
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Pro-Opiomelanocortin
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DNA
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preproenkephalin