[Effect of neurotransmitters and psychotropic drugs on the immune system. Mediator role of hormones and clinical implications]

Abstract

Neurotransmitters and psychotropic drugs may affect the immune system by direct action on immunocompetent cells or indirectly via hormonal secretions induced by these drugs. The effect of centrally acting drugs (lithium, antipsychotic, antiepileptic, hypotensive and opioid agents) on the immune system is reviewed and the mediator role of hormonal changes is assessed. Clinical implications resulting from these immune modulations are analyzed within the framework of autoimmune, allergic, infectious and neoplastic diseases.