Dynein arm substructure and the orientation of arm-microtubule attachments

J Mol Biol. 1984 Mar 5;173(3):389-401. doi: 10.1016/0022-2836(84)90127-x.

Abstract

In the presence of AMP-PCP (beta, gamma-methyleneadenosine 5'-triphosphate), a non-hydrolyzable analog of ATP, negative stain images of increased morphological detail indicate that the dynein arm, attached to ciliary doublet microtubules, is composed of subunits including a cape, an elongated body and a head. The arrangement of these subunits makes it possible to distinguish A from B subfiber binding sites on a single arm and to demonstrate that the head of an extended arm on subfiber A of one ciliary doublet is capable of binding to subfiber B of an adjacent doublet in a specific orientation, which supports a key step in a current model of the mechanochemical cycle by which the arm produces microtubule sliding in the ciliary axoneme.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Triphosphatases* / metabolism
  • Adenosine Triphosphate / analogs & derivatives
  • Animals
  • Dyneins* / metabolism
  • Macromolecular Substances
  • Microscopy, Electron
  • Microtubules / metabolism
  • Microtubules / ultrastructure*
  • Protein Conformation
  • Tetrahymena / analysis
  • Tetrahymena / ultrastructure

Substances

  • Macromolecular Substances
  • 5'-adenylyl (beta,gamma-methylene)diphosphonate
  • Adenosine Triphosphate
  • Adenosine Triphosphatases
  • Dyneins
  • alpha,beta-methyleneadenosine 5'-triphosphate