Hydroperoxyeicosatetraenoic acids. Potent inhibitors of lymphocyte responses

Biochim Biophys Acta. 1983 Mar 1;750(3):429-33. doi: 10.1016/0005-2760(83)90181-9.

Abstract

Arachidonic acid can be transformed into a series of HPETEs by the lipoxygenase enzyme activity of mouse peritoneal macrophages. These resulting HPETEs inhibit some mouse lymphocyte responses. When mice are injected with 15-L-HPETE, their splenocytes show a decreased [3H]thymidine uptake after lectin stimulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arachidonic Acids / metabolism
  • Arachidonic Acids / pharmacology*
  • Female
  • Lectins / pharmacology
  • Leukotrienes*
  • Lipid Peroxides*
  • Lipoxygenase / metabolism
  • Lymphocytes / drug effects*
  • Lymphocytes / immunology
  • Lymphocytes / physiology
  • Mice
  • Mice, Inbred C57BL
  • Spleen / drug effects
  • Thymidine / metabolism

Substances

  • Arachidonic Acids
  • Lectins
  • Leukotrienes
  • Lipid Peroxides
  • 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid
  • Lipoxygenase
  • Thymidine