Unusual clinical courses of adult T-cell leukemia in siblings

Cancer. 1984 Jul 1;54(1):131-4. doi: 10.1002/1097-0142(19840701)54:1<131::aid-cncr2820540126>3.0.co;2-q.

Abstract

Two siblings who developed adult T-cell leukemia (ATL) with unusual clinical courses are presented. The brother showed spontaneous remissions at the beginning stage of the disease of 6 years' duration, and the sister remains free of complaints for 6 years without chemotherapy. The patients and 2 of 12 healthy members of their family examined had serum antibodies against ATL-associated antigens (ATLA). The expression of ATLA was observed in the cultured lymphocytes from the patients and one of the family members.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, Neoplasm / analysis*
  • Cell Separation
  • Female
  • Humans
  • Leukemia / genetics*
  • Leukemia / immunology
  • Leukemia / pathology
  • Male
  • Membrane Glycoproteins*
  • Middle Aged
  • Pedigree
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / pathology

Substances

  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Membrane Glycoproteins
  • thymus-leukemia antigens