Abstract
Forty-nine postmenopausal patients with advanced breast cancer were treated with a nonsteroidal antiestrogen, Nafoxidine. The drug was generally well tolerated with dermatitis being the major toxic effect. A partial response in 12 of 40 patients, or 30%, was achieved with a median duration of response of greater than five months.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Breast Neoplasms / drug therapy*
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Drug Hypersensitivity / etiology
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Drug Therapy, Combination
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Female
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Humans
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Middle Aged
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Nafoxidine / adverse effects
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Nafoxidine / therapeutic use*
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Neoplasm Metastasis / drug therapy
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Neoplasm Recurrence, Local / drug therapy
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Prednisone / therapeutic use
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Pyrrolidines / therapeutic use*
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Receptors, Estrogen / drug effects
Substances
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Pyrrolidines
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Receptors, Estrogen
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Nafoxidine
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Prednisone