Comparison of simple sugar/salt versus glucose/electrolyte oral rehydration solutions in infant diarrhoea

J Trop Med Hyg. 1981 Oct;84(5):189-94.

Abstract

In a randomized double-blind trial, infants with mild or moderate diarrhoeal dehydration were rehydrated orally either with a simple solution containing table sugar and salt (without potassium or bicarbonate) or with a complete glucose/electrolyte formula. All 32 given glucose/electrolyte solution and 27 (93%) of 29 infants given sugar/salt were successfully rehydrated with similar improvement in metabolic acidosis and rapidity of rehydration. The drawbacks to oral therapy with simple sugar/salt solution were the frequent development of hypokalaemia and greater volume of vomiting during treatment. Carefully prepared sugar/salt solution, if accompanied by adequate potassium supplementation, may be used as an alternative to the preferred glucose/electrolyte formula when the latter is unavailable.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acidosis / etiology
  • Administration, Oral
  • Carbohydrates / therapeutic use
  • Clinical Trials as Topic
  • Dehydration / etiology
  • Dehydration / therapy
  • Diarrhea, Infantile / complications
  • Diarrhea, Infantile / therapy*
  • Double-Blind Method
  • Electrolytes / blood
  • Electrolytes / therapeutic use
  • Female
  • Fluid Therapy* / methods
  • Glucose / therapeutic use
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Random Allocation
  • Salts / therapeutic use
  • Solutions
  • Time Factors
  • Vomiting / etiology

Substances

  • Carbohydrates
  • Electrolytes
  • Salts
  • Solutions
  • Glucose