Are the Jarvik artificial ventricles limited by inflow resistance?

Artif Organs. 1981 May;5(2):118-24. doi: 10.1111/j.1525-1594.1981.tb03973.x.

Abstract

The pneumatic total artificial heart has been assumed to be inflow limited. Mock circulation studies on the Jarvik-5 and Jarvik-7 artificial ventricles seemed to support this assumption because a Starling's response comparable to the natural heart was not achieved. Unfortunately, mock circulation studies do not separate the effects of valvular regurgitation from inflow resistance. By using a simple filling tank, filling times were determined for the Jarvik ventricles that were a function of inflow resistance alone. Theoretical maximum cardiac outputs based on these inflow resistance-dependent filling times were then calculated. For filling pressures around 5 mmHg and under modest diastolic vacuum of 5 cm H2O, the Jarvik ventricles yield a theoretical cardiac output as good as the natural heart's. Thus, inflow resistance is not a limiting factor and valvular regurgitation is left as the most likely cause of a less than optimal Starling's response on mock circulation and in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cardiac Output
  • Diastole
  • Heart Rate
  • Heart Ventricles
  • Heart, Artificial* / instrumentation
  • Humans
  • Rheology*