The burn disease increases the intensity of lipid peroxidation in the guinea pigs plasma and liver. Under these conditions in the liver the content of ascorbic acid lowers and a high level of reduced glutathione is maintained due to an increase in the glucose-6-phosphate dehydrogenase activity. Disproteinemia is observed in plasma. Administration of alpha-tocopherol and sodium selenite to animals with the burn disease inhibits lipids peroxidation, favours the retaining of the ascorbic acid content in the liver tissue, prevents a compensatory increase in the glucose-6-phosphate dehydrogenase activity and a rise in the level of reduced glutathione. It also weakens disproteinemia in plasma.