This report is a list of simple but effective techniques for marking important structures intra-operatively. During the last 2 years in 52 patients intra-operative marking techniques have been used. In 37 cases a small piece of fat has been taken. In 10 patients it was done by a radiopaque Barium impregnated silicon sphere and in 5 patients with a piece of a monofilament suture. Postoperative checks were done by conventional X-ray, computer tomography and Magnetic Resonance Imaging. The indication in all cases was to offer landmarks helpful for planning postoperative radiosurgery. In case of fat and radiopaque Barium impregnated silicone spheres the markings were always well defined and clear in contrast. In those cases where a piece of monofilament suture was used it was impossible to get clear postoperative information. In general there were no intra- or post-operative complications. All markers were well tolerated and no side effects have been observed so far. The advantages and disadvantages of each of these possibilities are described and discussed.