Abstract
Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, CD / genetics
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Antigens, CD / physiology*
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Antigens, Differentiation, B-Lymphocyte / genetics
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Antigens, Differentiation, B-Lymphocyte / physiology*
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CD40 Antigens
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CD40 Ligand
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Humans
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Immunoglobulin Class Switching / immunology*
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Immunologic Deficiency Syndromes / genetics
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Immunologic Deficiency Syndromes / immunology
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Ligands
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology*
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Signal Transduction / immunology
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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CD40 Antigens
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Ligands
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Membrane Glycoproteins
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CD40 Ligand