Treatment of advanced medullary thyroid cancer with an alternating combination of 5 FU-streptozocin and 5 FU-dacarbazine. The Groupe d'Etude des Tumeurs a Calcitonine (GETC)

M Schlumberger; N Abdelmoumene; M J Delisle; J E Couette

doi:10.1038/bjc.1995.73

Treatment of advanced medullary thyroid cancer with an alternating combination of 5 FU-streptozocin and 5 FU-dacarbazine. The Groupe d'Etude des Tumeurs a Calcitonine (GETC)

Br J Cancer. 1995 Feb;71(2):363-5. doi: 10.1038/bjc.1995.73.

Authors

M Schlumberger¹, N Abdelmoumene, M J Delisle, J E Couette

Affiliation

¹ Institut Gustave-Roussy, Villejuif, France.

Abstract

Combinations of 5-fluorouracil (5-FU) and streptozocin and 5-FU and dacarbazine were given alternately to 20 patients with metastatic medullary thyroid carcinoma. Three partial responses and 11 long-term stabilizations were observed. No unexpected toxicity occurred.

Publication types

Clinical Trial

MeSH terms

Adult
Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Medullary / drug therapy*
Carcinoma, Medullary / pathology
Carcinoma, Medullary / surgery
Combined Modality Therapy
Dacarbazine / administration & dosage
Drug Administration Schedule
Female
Fluorouracil / administration & dosage
Humans
Male
Middle Aged
Neoplasm Metastasis
Palliative Care*
Radiotherapy, Adjuvant
Streptozocin / administration & dosage
Thyroid Neoplasms / drug therapy*
Thyroid Neoplasms / pathology
Thyroid Neoplasms / radiotherapy
Thyroid Neoplasms / surgery
Thyroidectomy
Treatment Outcome

Substances

Streptozocin
Dacarbazine
Fluorouracil