Low-dose ultraviolet B pretreatment of human islets reduces graft immunogenicity through the induction of antigen-presenting cell apoptosis without adversely affecting insulin secretion

Transplant Proc. 1995 Feb;27(1):1347-8.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apoptosis / radiation effects*
  • Blood Glucose / metabolism
  • Cell Adhesion Molecules / analysis
  • Cell Adhesion Molecules / biosynthesis
  • Cell Line
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / therapy
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / therapy*
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / immunology
  • Endothelium, Vascular / radiation effects
  • Flow Cytometry
  • HLA-D Antigens / analysis
  • HLA-D Antigens / biosynthesis
  • Histocompatibility Antigens Class I / analysis
  • Histocompatibility Antigens Class I / biosynthesis
  • Humans
  • Insulin / metabolism*
  • Insulin Secretion
  • Interferon-gamma / pharmacology
  • Islets of Langerhans / radiation effects*
  • Islets of Langerhans Transplantation / immunology*
  • Islets of Langerhans Transplantation / physiology
  • Mice
  • Mice, Nude
  • Monocytes
  • Rats
  • Rats, Nude
  • Recombinant Proteins
  • Transplantation, Heterologous / immunology*
  • Transplantation, Heterologous / physiology
  • Ultraviolet Rays*
  • Umbilical Veins
  • Vascular Cell Adhesion Molecule-1

Substances

  • Blood Glucose
  • Cell Adhesion Molecules
  • HLA-D Antigens
  • Histocompatibility Antigens Class I
  • Insulin
  • Recombinant Proteins
  • Vascular Cell Adhesion Molecule-1
  • Interferon-gamma