Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene

B M Brinkman; E L Kaijzel; T W Huizinga; M J Giphart; F C Breedveld; C L Verweij

doi:10.1007/BF00191815

Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene

Hum Genet. 1995 Oct;96(4):493. doi: 10.1007/BF00191815.

Authors

B M Brinkman¹, E L Kaijzel, T W Huizinga, M J Giphart, F C Breedveld, C L Verweij

Affiliation

¹ Department of Rheumatology, University Hospital Leiden, The Netherlands.

PMID: 7557979
DOI: 10.1007/BF00191815

Abstract

We have identified a C-insertion polymorphism in the 5'UTR of the first exon of the human tumor necrosis factor alpha (TNFA) gene. TNFA is a cytokine that plays an important role in the inflammatory response.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Chromosomes, Human, Pair 6
DNA Transposable Elements / genetics*
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Single-Stranded Conformational
Tumor Necrosis Factor-alpha / genetics*

Substances

DNA Transposable Elements
Tumor Necrosis Factor-alpha