Abstract
The suppression of faecal Escherichia coli by quinolones was studied in a randomized cross-over phase I trial with single oral doses of 400 mg rufloxacin or norfloxacin. Both drugs caused > 70% decontamination in a similar number of subjects in the 72 h post-dose period (83% vs 100% respectively), but suppression of E. coli at 168 h was significantly (P < 0.05) higher after rufloxacin (83.3 vs 40%).
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Infective Agents / pharmacokinetics
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Anti-Infective Agents / pharmacology*
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Bacteroides fragilis / drug effects
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Colony Count, Microbial
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Escherichia coli / drug effects
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Feces / chemistry
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Feces / microbiology*
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Fluoroquinolones*
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Humans
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Male
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Norfloxacin / pharmacokinetics
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Norfloxacin / pharmacology*
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Quinolones / pharmacokinetics
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Quinolones / pharmacology*
Substances
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Anti-Infective Agents
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Fluoroquinolones
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Quinolones
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Norfloxacin
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rufloxacin