Bleomycin sclerotherapy in patients with congenital lymphatic malformation in the head and neck

Am J Otolaryngol. 1995 Jul-Aug;16(4):236-41. doi: 10.1016/0196-0709(95)90149-3.

Abstract

Congenital lymphatic malformations of the head and neck often present challenging problems to the otolaryngologist-head and neck surgeon. Although surgical excision was agreed to be the treatment of choice for this disease, the infiltrating nature of lymphatic channels often increases the frequency of operative complications and recurrences of this lesion.

Purpose: Bleomycin sclerotherapy was attempted to avoid surgical risk and to cure this lesion.

Materials and methods: Clinical findings and treatment results were reviewed for patients with congenital lymphatic malformation and treated by bleomycin sclerotherapy.

Results: Bleomycin sclerotherapy was a very effective therapeutic alternative. The best results were seen in cystic type 1 lesions in younger patients.

Conclusions: Bleomycin sclerotherapy is a useful medical alternative, and we believe that it should be attempted before excision of the lesion.

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Bleomycin / therapeutic use*
  • Child
  • Female
  • Head / pathology
  • Head and Neck Neoplasms / congenital*
  • Head and Neck Neoplasms / drug therapy*
  • Head and Neck Neoplasms / pathology
  • Hemangioma / congenital*
  • Hemangioma / drug therapy*
  • Hemangioma / pathology
  • Humans
  • Infant, Newborn
  • Male
  • Neck / pathology
  • Sclerotherapy*
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Bleomycin