Poly(ADP-ribose) polymerase: structure-function relationship

Biochimie. 1995;77(6):456-61. doi: 10.1016/0300-9084(96)88160-0.

Abstract

Dissection of the human poly(ADP-ribose) polymerase (PARP) molecule in terms of its structure-function relationship has proved to be an essential step towards understanding the biological role of poly(ADP-ribosylation) as a cellular response to DNA damage in eukaryotes. Current approaches aimed at elucidating the implication of this multifunctional enzyme in the maintenance of the genomic integrity will be presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalysis
  • Chickens
  • Crystallization
  • Crystallography, X-Ray
  • DNA Damage
  • DNA Repair*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / physiology
  • Genome, Human
  • HeLa Cells
  • Humans
  • Poly(ADP-ribose) Polymerases / chemistry*
  • Poly(ADP-ribose) Polymerases / physiology*
  • Protein Structure, Tertiary
  • Recombinant Proteins / chemistry
  • Structure-Activity Relationship
  • Transfection

Substances

  • DNA-Binding Proteins
  • Recombinant Proteins
  • Poly(ADP-ribose) Polymerases