Abstract
Cytokine therapy of metastatic renal cell carcinoma reveals a remission rate of about 25% regarding to the different patients selection criteria, i.e. age, performance status, site of metastasis, tumour load. Remission is not correlated to patient's survival. Adjuvant or neoadjuvant immunotherapy is not a treatment option. Nephrectomy has no influence on distant metastases and should be limited to symptomatic primary tumours. In conclusion, cytokine therapy is not a standard treatment. Its value has to be evaluated in randomized trials.
Publication types
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Clinical Trial
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Clinical Trial, Phase II
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Comparative Study
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Randomized Controlled Trial
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Review
MeSH terms
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Carcinoma, Renal Cell / immunology
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Carcinoma, Renal Cell / mortality
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Carcinoma, Renal Cell / therapy*
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Combined Modality Therapy
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Cytokines / adverse effects
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Cytokines / therapeutic use*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Humans
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Injections, Subcutaneous
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Interferon alpha-2
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Interferon-alpha / administration & dosage
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Interferon-alpha / adverse effects
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Interferon-gamma / administration & dosage
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Interferon-gamma / adverse effects
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Interleukin-2 / administration & dosage
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Interleukin-2 / adverse effects
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Kidney Neoplasms / immunology
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Kidney Neoplasms / mortality
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Kidney Neoplasms / therapy*
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Neoplasm Metastasis
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Prognosis
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Recombinant Proteins
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Survival Rate
Substances
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Cytokines
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Interferon alpha-2
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Interferon-alpha
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Interleukin-2
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Recombinant Proteins
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Interferon-gamma