[Cytokine therapy of metastatic renal cell carcinoma]

Urologe A. 1995 May;34(3):200-3.
[Article in German]

Abstract

Cytokine therapy of metastatic renal cell carcinoma reveals a remission rate of about 25% regarding to the different patients selection criteria, i.e. age, performance status, site of metastasis, tumour load. Remission is not correlated to patient's survival. Adjuvant or neoadjuvant immunotherapy is not a treatment option. Nephrectomy has no influence on distant metastases and should be limited to symptomatic primary tumours. In conclusion, cytokine therapy is not a standard treatment. Its value has to be evaluated in randomized trials.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II
  • Comparative Study
  • Randomized Controlled Trial
  • Review

MeSH terms

  • Carcinoma, Renal Cell / immunology
  • Carcinoma, Renal Cell / mortality
  • Carcinoma, Renal Cell / therapy*
  • Combined Modality Therapy
  • Cytokines / adverse effects
  • Cytokines / therapeutic use*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Humans
  • Injections, Subcutaneous
  • Interferon alpha-2
  • Interferon-alpha / administration & dosage
  • Interferon-alpha / adverse effects
  • Interferon-gamma / administration & dosage
  • Interferon-gamma / adverse effects
  • Interleukin-2 / administration & dosage
  • Interleukin-2 / adverse effects
  • Kidney Neoplasms / immunology
  • Kidney Neoplasms / mortality
  • Kidney Neoplasms / therapy*
  • Neoplasm Metastasis
  • Prognosis
  • Recombinant Proteins
  • Survival Rate

Substances

  • Cytokines
  • Interferon alpha-2
  • Interferon-alpha
  • Interleukin-2
  • Recombinant Proteins
  • Interferon-gamma