Isochromophilones III-VI, inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium multicolor FO-3216

J Antibiot (Tokyo). 1995 Jul;48(7):696-702. doi: 10.7164/antibiotics.48.696.

Abstract

New azaphilones named isochromophilones III-VI were isolated from the culture broth of Penicillium multicolor FO-3216 as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Their structures were elucidated by NMR and other spectroscopic analyses. The IC50 values of isochromophilones III, IV, V and VI for ACAT activity in an enzyme assay using rat liver microsomes were calculated to be 110, 50, 50 and 120 microM, respectively.

MeSH terms

  • Animals
  • Benzopyrans / chemistry
  • Benzopyrans / isolation & purification*
  • Benzopyrans / pharmacology*
  • Fermentation
  • Microbial Sensitivity Tests
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • Molecular Structure
  • Penicillium
  • Rats
  • Stereoisomerism
  • Sterol O-Acyltransferase / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Benzopyrans
  • isochromophilone III
  • isochromophilone IV
  • isochromophilone V
  • isochromophilone VI
  • Sterol O-Acyltransferase