New antibiotics phthoxazolins B, C and D produced by Streptomyces sp. KO-7888

J Antibiot (Tokyo). 1995 Jul;48(7):714-9. doi: 10.7164/antibiotics.48.714.

Abstract

New antibiotics, phthoxazolins B, C and D were isolated from the fermentation broth of Streptomyces sp. KO-7888. They are geometrical isomers of 10-hydroxyphthoxazolin A. They showed selective antifungal activity against Phytophthora parasitica in vitro and modest herbicidal activity in a laboratory test, but the potencies were different among isomers.

Publication types

  • Comparative Study

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification*
  • Fatty Alcohols / pharmacology
  • Fermentation
  • Herbicides / chemistry
  • Herbicides / isolation & purification*
  • Herbicides / pharmacology
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Oxazoles / chemistry
  • Oxazoles / isolation & purification*
  • Oxazoles / pharmacology
  • Streptomyces
  • Structure-Activity Relationship

Substances

  • 10-hydroxyphthoxazolin A
  • Antifungal Agents
  • Fatty Alcohols
  • Herbicides
  • Oxazoles