Cytotoxic T lymphocyte epitopes shared between HIV-1, HIV-2, and SIV

J Med Primatol. 1993 Feb-May;22(2-3):119-23.

Abstract

A peptide epitope from the gag protein of SIV and from HIV-1 is described which is presented by a cynomolgus macaque MHC molecule and with HLA B14. Comparisons were drawn between recognition of this peptide and that of a second peptide defined in SIV and HIV-2 which has been reported to be presented by the rhesus macaque molecule MaMuA01 and HLA B53 respectively.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigen Presentation
  • Antigens, Viral / genetics
  • Epitopes / genetics
  • Gene Products, gag / genetics
  • Gene Products, gag / immunology
  • HIV Infections / immunology
  • HIV-1 / genetics
  • HIV-1 / immunology*
  • HIV-2 / genetics
  • HIV-2 / immunology*
  • HLA-B Antigens
  • HLA-B14 Antigen
  • Histocompatibility Antigens
  • Humans
  • In Vitro Techniques
  • Macaca fascicularis
  • Male
  • Molecular Sequence Data
  • Simian Immunodeficiency Virus / genetics
  • Simian Immunodeficiency Virus / immunology*
  • Species Specificity
  • T-Lymphocytes, Cytotoxic / immunology*
  • Vaccination

Substances

  • Antigens, Viral
  • Epitopes
  • Gene Products, gag
  • HLA-B Antigens
  • HLA-B14 Antigen
  • Histocompatibility Antigens