New glycosidases inhibitors, panosialins D and wD produced by Streptomyces sp. OH-5186

J Antibiot (Tokyo). 1995 Mar;48(3):205-10. doi: 10.7164/antibiotics.48.205.

Abstract

New panosialin analog, panosialins D and wD have been isolated from the culture broth of Streptomyces sp. OH-5186. Their structures were elucidated as 5-(13-methylpentadecyl)-1,3-benzenediol bis(sodium sulfate) and 5-(13-methylpentadecyl)-1,3-benzenediol 1-(sodium sulfate), respectively. They showed strong inhibitory activity against alpha-mannosidase, alpha-glucosidase, and beta-glucosidase. Panosialins wA-wD mixture also showed weak mitogenic activity but suppressed the mitogen induced activity.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Antiviral Agents / chemistry*
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Glycoside Hydrolases / antagonists & inhibitors*
  • Male
  • Mice
  • Mice, Inbred ICR
  • Microbial Sensitivity Tests
  • Mitogens / pharmacology
  • Orthomyxoviridae / drug effects
  • Resorcinols / chemistry
  • Resorcinols / isolation & purification*
  • Resorcinols / pharmacology
  • Streptomyces / metabolism*

Substances

  • Anti-Bacterial Agents
  • Antiviral Agents
  • Mitogens
  • Resorcinols
  • panosialin D
  • panosialin wD
  • Glycoside Hydrolases