Colonic dilatation due to dialysis-related amyloidosis

Am J Kidney Dis. 1995 May;25(5):807-9. doi: 10.1016/0272-6386(95)90559-6.

Abstract

A 66-year-old woman with chronic renal failure who had undergone hemodialysis for 15 years developed severe dilatation of the ascending and transverse colon. She had received right carpal tunnel release 5 years before this episode. The follow-up study of upper gastrointestinal series disclosed marked dilatation of the ascending and transverse colon with the retention of gastrografin persisted for 5 days, whereas colonic fiberscope showed no obstructive lesion. Pathologic study of biopsy specimens obtained from the colon demonstrated amyloid deposition. Avidin-biotin peroxidase complex method showed that these deposits strongly reacted with the antibody to human beta 2-microglobulin, but did not react with AA, lambda, and kappa antibodies. This case suggests that dialysis-related amyloidosis can cause intestinal pseudo-obstruction.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amyloidosis / complications
  • Amyloidosis / etiology*
  • Carpal Tunnel Syndrome / etiology
  • Colonic Diseases / diagnostic imaging
  • Colonic Diseases / etiology*
  • Dilatation, Pathologic / diagnostic imaging
  • Dilatation, Pathologic / etiology
  • Female
  • Humans
  • Radiography
  • Renal Dialysis / adverse effects*