Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice

Biochem Genet. 1994 Dec;32(11-12):397-407. doi: 10.1007/BF00566060.

Abstract

Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (apo A-II). QTL analysis revealed a significant locus on chromosome 1 distal impacting serum apo A-II concentration on a high-fat diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumably Apoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apolipoprotein A-I / blood
  • Apolipoprotein A-II / blood
  • Arteriosclerosis / blood
  • Arteriosclerosis / etiology
  • Arteriosclerosis / genetics*
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, VLDL / blood
  • Diet, Atherogenic*
  • Genetic Predisposition to Disease
  • Mice
  • Mice, Inbred C3H / genetics*
  • Mice, Inbred C57BL / genetics*
  • Phenotype
  • Probability
  • Recombination, Genetic*
  • Species Specificity

Substances

  • Apolipoprotein A-I
  • Apolipoprotein A-II
  • Cholesterol, HDL
  • Cholesterol, VLDL
  • Cholesterol