Intranigral injected iron progressively reduces striatal dopamine metabolism

W Wesemann; S Blaschke; M Solbach; C Grote; H W Clement; P Riederer

doi:10.1007/BF02260941

Intranigral injected iron progressively reduces striatal dopamine metabolism

J Neural Transm Park Dis Dement Sect. 1994;8(3):209-14. doi: 10.1007/BF02260941.

Authors

W Wesemann¹, S Blaschke, M Solbach, C Grote, H W Clement, P Riederer

Affiliation

¹ Department of Neurochemistry, Institute of Physiological Chemistry, Marburg, Federal Republic of Germany.

PMID: 7748464
DOI: 10.1007/BF02260941

Abstract

The striatal dopamine metabolism of the rat was followed 1, 3, and 6 weeks after unilateral intranigral iron (III) (50- and 1.5 micrograms) application. For both concentrations a progredient decrease of extraneuronal 3.4-dihydroxyphenylacetic acid (DOPA) levels was observed in the ipsilateral striatum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3,4-Dihydroxyphenylacetic Acid / metabolism*
Animals
Corpus Striatum / drug effects*
Corpus Striatum / metabolism
Dopamine / metabolism*
Ferric Compounds / administration & dosage
Ferric Compounds / pharmacology*
Injections
Male
Parkinson Disease / metabolism
Rats
Rats, Wistar
Substantia Nigra / drug effects*

Substances

Ferric Compounds
3,4-Dihydroxyphenylacetic Acid
Dopamine