Protection of goats against peste des petits ruminants with recombinant capripoxviruses expressing the fusion and haemagglutinin protein genes of rinderpest virus

Vaccine. 1995 Jan;13(1):36-40. doi: 10.1016/0264-410x(95)80008-2.

Abstract

Goats were protected against a lethal challenge of peste des petits ruminants (PPR) virus following vaccination with a recombinant capripoxvirus containing either the fusion (F) gene of rinderpest virus or the haemagglutinin (H) gene of rinderpest virus. The H gene recombinant produced high titres of neutralizing antibody to rinderpest virus in the vaccinated goats, whereas the F gene recombinant failed to stimulate detectable levels of neutralizing antibody. A similar response to the two recombinant vaccines has previously been reported for cattle. Neither recombinant produced detectable levels of specific antibodies to PPR virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Capripoxvirus / genetics*
  • Cloning, Molecular
  • Genes, Viral
  • Genetic Vectors
  • Goat Diseases / prevention & control*
  • Goats
  • Hemagglutinins / genetics
  • Morbillivirus Infections / prevention & control
  • Morbillivirus Infections / veterinary*
  • Peste-des-petits-ruminants virus / immunology*
  • Rinderpest virus / genetics
  • Vaccines, Synthetic / therapeutic use*
  • Viral Proteins / genetics
  • Viral Vaccines / therapeutic use*

Substances

  • Hemagglutinins
  • Vaccines, Synthetic
  • Viral Proteins
  • Viral Vaccines