A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics

J Antibiot (Tokyo). 1993 Nov;46(11):1666-71. doi: 10.7164/antibiotics.46.1666.

Abstract

A new peptide antibiotic, cypemycin, with a molecular weight of 2,097 (M+H), was isolated from the culture broth of Streptomyces sp. OH-4156. The antibiotic possesses cytocidal activity against P388 leukemia cells in vitro at a concentration of 1.3 microgram/ml (IC50 values), and the antibiotic showed antimicrobial activities against Micrococcus luteus (MIC, 0.2 microgram/ml).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anti-Bacterial Agents*
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Bacteriocins
  • Fermentation
  • Humans
  • Leukemia P388 / drug therapy
  • Mice
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Peptides / isolation & purification*
  • Peptides / pharmacology
  • Streptomyces / chemistry*
  • Tumor Cells, Cultured / drug effects

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Bacteriocins
  • Peptides
  • cypemycin