Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer

G Scambia; U Testa; P Benedetti Panici; E Foti; R Martucci; A Gadducci; A Perillo; V Facchini; C Peschle; S Mancuso

doi:10.1038/bjc.1995.71

Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer

Br J Cancer. 1995 Feb;71(2):354-6. doi: 10.1038/bjc.1995.71.

Authors

G Scambia¹, U Testa, P Benedetti Panici, E Foti, R Martucci, A Gadducci, A Perillo, V Facchini, C Peschle, S Mancuso

Affiliation

¹ Department of Gynecology and Obstetrics, Catholic University, Rome, Italy.

Abstract

High levels of IL-6 were found in 50% of 114 patients with primary ovarian cancer. IL-6 sensitivity was lower than that of CA 125, and the combination of both assays did not increase the sensitivity of CA 125 alone. However, elevated IL-6 serum levels were correlated with a poor prognosis since patients with low IL-6 levels had a better survival than patients with high IL-6 levels (P = 0.0009). Multivariate analysis revealed that IL-6 positivity has an independent value.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Ascites
Biomarkers, Tumor / blood*
CA-125 Antigen / blood
Female
Humans
Interleukin-6 / blood*
Life Tables
Middle Aged
Multivariate Analysis
Neoplasm Proteins / blood*
Neoplasm Staging
Ovarian Neoplasms / blood*
Ovarian Neoplasms / mortality*
Ovarian Neoplasms / pathology
Prognosis
Sensitivity and Specificity
Survival Analysis

Substances

Biomarkers, Tumor
CA-125 Antigen
Interleukin-6
Neoplasm Proteins