Abstract
Multidrug resistance in tumor cells is often caused by the increased efflux of a wide variety of drugs, mediated by P glycoprotein, a member of the superfamily of ATP-binding cassette (ABC) transporters. The genes encoding members of this superfamily have also been isolated from drug-resistant microorganisms, and the role of microbial ABC transporters in drug resistance is being investigated.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology
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ATP-Binding Cassette Transporters / genetics
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ATP-Binding Cassette Transporters / physiology*
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Animals
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Bacteria / genetics
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Drug Resistance, Multiple / genetics
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Drug Resistance, Multiple / physiology*
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Humans
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Leishmania / genetics
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Mice
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Neoplasms / physiopathology
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Plasmodium / genetics
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Yeasts / genetics
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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ATP-Binding Cassette Transporters