Establishment of multiple leukemia cell lines with diverse myeloid and/or megakaryoblastoid characteristics from a single Ph1 positive chronic myelogenous leukemia blood sample

K Tsuji-Takayama; T Kamiya; S Nakamura; Y Matsuo; T Adachi; T Tsubota; J Imanishi; J Minowada

Establishment of multiple leukemia cell lines with diverse myeloid and/or megakaryoblastoid characteristics from a single Ph1 positive chronic myelogenous leukemia blood sample

Hum Cell. 1994 Sep;7(3):167-71.

Authors

K Tsuji-Takayama¹, T Kamiya, S Nakamura, Y Matsuo, T Adachi, T Tsubota, J Imanishi, J Minowada

Affiliation

¹ Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc.

PMID: 7873501

Abstract

Seven cell lines, MOLM-6, -7, -8, -9, -10, -11 and -12, were established from a single blood sample from a patient with chronic myelogenous leukemia (CML) in blastic phase having the Ph1 chromosome abnormality. Based on immunophenotyping, two of these seven cell lines, MOLM-7 and -11, represented the megakaryoblastoid lineage, and the other five cell lines represented two different maturation stages of the myeloid lineage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bone Marrow / pathology
Cell Line*
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
Male
Megakaryocytes / pathology
Tumor Cells, Cultured