The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C

Gene. 1994 Sep 30;147(2):299-300. doi: 10.1016/0378-1119(94)90087-6.

Abstract

We report here the cloning of the murine cDNA encoding caveolin, a known v-Src substrate and caveolar marker protein. Interestingly, analysis of the murine cDNA and comparison with caveolin from other species reveals a previously unrecognized consensus site for protein kinase C (PKC) phosphorylation. This finding could have important implications as (i) both the morphology and function of caveolae are dramatically affected by PKC activators; and (ii) PKC alpha is concentrated in isolated caveolin-rich membrane domains. In addition, this first step should facilitate the use of the mouse as a genetic system for elucidating the role of caveolin in caveolar functioning.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Caveolin 1
  • Caveolins*
  • Cloning, Molecular
  • Conserved Sequence
  • DNA, Complementary
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mice
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Kinase C / metabolism*
  • Sequence Homology, Amino Acid

Substances

  • CAV1 protein, human
  • Cav1 protein, mouse
  • Caveolin 1
  • Caveolins
  • DNA, Complementary
  • Membrane Proteins
  • Protein Kinase C

Associated data

  • GENBANK/U07645