Pharmacokinetics and pharmacodynamics of tizanidine

Neurology. 1994 Nov;44(11 Suppl 9):S29-31.

Abstract

The relationship among tizanidine dose, plasma concentration, and antispastic action is linear in nature. Response to a given dose of this agent varies among patients, and determining the appropriate clinical dose requires individual titration.

Publication types

  • Review

MeSH terms

  • Clonidine / administration & dosage
  • Clonidine / analogs & derivatives*
  • Clonidine / pharmacokinetics
  • Dose-Response Relationship, Drug
  • Humans
  • Muscle Relaxants, Central / administration & dosage*
  • Muscle Relaxants, Central / pharmacokinetics*
  • Muscle Spasticity / blood
  • Muscle Spasticity / drug therapy*
  • Muscle Spasticity / physiopathology

Substances

  • Muscle Relaxants, Central
  • tizanidine
  • Clonidine