Salivary testosterone and cortisol in disruptive children: relationship to aggressive, hyperactive, and internalizing behaviors

J Am Acad Child Adolesc Psychiatry. 1994 Oct;33(8):1174-84. doi: 10.1097/00004583-199410000-00013.

Abstract

Objective: To test predictions that basal salivary testosterone and cortisol are related to antisocial and internalizing behaviors, respectively, and that cortisol moderates the testosterone-aggression relationship.

Method: Saliva samples were assayed to determine testosterone and cortisol levels in 40 clinic-referred disruptive children (aged 7 through 14 years) who were rated on aggression, inattention/overactivity, and internalizing behavior by parents, teachers, and clinic staff members.

Results: Results indicated significant positive relationships between testosterone and staff-rated aggression and between cortisol and parent-rated internalizing behavior. A significant negative relationship was found between cortisol and staff-rated inattention/overactivity. No interactions between testosterone and cortisol were found. These results were maintained regardless of age, racial background, height, weight, diagnosis, or medication status.

Conclusions: Results suggest moderate relationships between testosterone and observed aggression, and between cortisol and emotional behaviors, in a group of disruptive children. Cortisol did not moderate the testosterone-aggression relationship in this population.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Aggression / physiology*
  • Aggression / psychology
  • Attention Deficit Disorder with Hyperactivity / diagnosis
  • Attention Deficit Disorder with Hyperactivity / physiopathology*
  • Attention Deficit Disorder with Hyperactivity / psychology
  • Child
  • Child Behavior Disorders / diagnosis
  • Child Behavior Disorders / physiopathology*
  • Child Behavior Disorders / psychology
  • Female
  • Humans
  • Hydrocortisone / metabolism*
  • Internal-External Control*
  • Male
  • Personality Assessment
  • Saliva / metabolism*
  • Testosterone / metabolism*

Substances

  • Testosterone
  • Hydrocortisone