Analysis of repetitive and nonrepetitive sequential arm movements in patients with Parkinson's disease

Mov Disord. 1994 May;9(3):311-4. doi: 10.1002/mds.870090305.

Abstract

We examined the motor performance of Parkinson's disease patients and normal subjects during nonrepetitive and repetitive sequential tasks. Parkinson's disease patients took longer than normal subjects to complete the nonrepetitive task, the sequential drawing of a pentagon. In patients, movement times lengthened as the sequence neared completion. The amount of lengthening was similar in nonrepetitive and repetitive tasks (sequential alternating drawing of each side of the pentagon). In parkinsonian patients the slowing at the end of the sequential tasks does not appear to be influenced by whether the sequential task involves nonrepetitive or repetitive movements.

MeSH terms

  • Adult
  • Aged
  • Corpus Striatum / physiopathology
  • Dopamine / physiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Motor Skills / physiology*
  • Neural Pathways / physiopathology
  • Parkinson Disease / diagnosis
  • Parkinson Disease / physiopathology*
  • Psychomotor Performance / physiology*
  • Reaction Time / physiology*
  • Reference Values
  • Substantia Nigra / physiopathology

Substances

  • Dopamine