Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine

C Perigaud; A M Aubertin; S Benzaria; H Pelicano; J L Girardet; G Maury; G Gosselin; A Kirn; J L Imbach

doi:10.1016/0006-2952(94)90217-8

Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine

Biochem Pharmacol. 1994 Jul 5;48(1):11-14. doi: 10.1016/0006-2952(94)90217-8.

Authors

C Perigaud¹, A M Aubertin, S Benzaria, H Pelicano, J L Girardet, G Maury, G Gosselin, A Kirn, J L Imbach

Affiliation

¹ Laboratoire de Chimie Bio-Organique, U.R.A. 488 du C.N.R.S., Université de Montpellier II, France.

PMID: 8043011
DOI: 10.1016/0006-2952(94)90217-8

Abstract

It is shown that ddA bis(SATE)phosphotriester is one of the most potent anti-HIV agents in cell culture. Compared with the parent nucleoside, ddA, an increase of 3 orders of magnitude was observed in the EC50, which makes this compound as active as AZT. This can be tentatively explained if one considers that direct ddAMP intracellular delivery shunts the well established ddA/ddI metabolism pathway.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / pharmacology*
Cell Line
Dideoxyadenosine / analogs & derivatives
Dideoxyadenosine / pharmacology*
Drug Evaluation, Preclinical
HIV / drug effects*
HIV / physiology
Humans
T-Lymphocytes / microbiology*
Virus Replication / drug effects*
Zidovudine / pharmacology*

Substances

Antiviral Agents
Zidovudine
Dideoxyadenosine