106 ENT localized carcinomas (97 men and 9 women) in adults under 45 years old are reviewed. The mean age was 40.0 years old and most suffered from an alcoholic and/or nicotine addiction. 89.6% expressed an epidermoid carcinoma and buccal cavity and larynx lesions represented the most frequent locations, followed by the pharynx. Overall survival does not differ from that of an older population but some locations seem to have a very poor prognosis: mobile tongue, vallecula, piriform sinus and amygdala. On the other hand, the laryngeal locations confirm their favorable prognosis.